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In a place far, far away, illegal genetic experiment #626 is detected. The experiment is supposed to be transported to a prison asteroid, yet manages to escape. With a stolen police cruiser, the destructive being races toward Earth. Stranded on Hawaii, experiment #626 can't actually do much harm. A little girl, Lilo, adopts the experiment as dog, gives him the name Stitch and actually causes an emotional development in the little beast. Her dysfunctional family, consisting only of Lilo and her sister Nani, is about to be ripped apart by a social worker. Stitch as the new family member brings quite some action into all their lives.