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In 1998 Professor Nick Cutter's wife Helen disappeared through a rupture in time known as an anomaly. Eight years later anomalies to different points in Earth's history are beginning to appear all over London, bringing with them dangerous prehistoric creatures. To combat the anomaly threat, government officials James Lester and Claudia Brown form a research team led by Professor Cutter (in later series, Danny Quinn and Matt Anderson) with the aim of capturing the creatures and sending them back to their own time.